Determination of sodium hyaluronate in pharmaceutical formulations by HPLC–UV

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Determination of sodium hyaluronate in pharmaceutical formulations by HPLC–UV

A liquid chromatography (HPLC) method with UV detection was developed for determination of sodium hyaluronate in pharmaceutical formulation. Sodium hyaluronate is a polymer of disaccharides, composed of d-glucuronic acid and d-N-acetylglucosamine, linked via alternating β-1, 4 and β-1, 3 glycosidic bonds. Being a polymer compound it lacks a UV absorbing chromophore. In the absence of a UV absor...

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ژورنال

عنوان ژورنال: Journal of Pharmaceutical Analysis

سال: 2013

ISSN: 2095-1779

DOI: 10.1016/j.jpha.2013.02.001